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Another GLP-1 analogue, lixisenatide, was reported to prevent the acuteness of cardiovascular events in apolipoprotein E −/− insulin receptor substrate 2 +/− (APOE −/− irs2 +/− ) mice by reducing the size of AS plaques, increasing plaque stability, and promoting the conversion of macrophages to the anti-inflammatory M2 phenotype (129)
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Semaglutide is a prescription GLP-1 receptor agonist used, alongside diet and exercise, to support weight management and blood-sugar regulation in eligible adults
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